Alpha interferon in the treatment of symptomatic myelofibrosis with myeloid metaplasia

Eur J Haematol. 1987 Sep;39(3):228-32. doi: 10.1111/j.1600-0609.1987.tb00762.x.

Abstract

2 patients with myelofibrosis and myeloid metaplasia had symptomatic splenomegaly and were treated with interferon alpha-2c (IFN alpha-2c). The splenic pain and pressure symptoms disappeared, accompanied by a decrease in the size of the spleen. However, the peripheral blood count worsened and no improvement in the bone marrow fibrosis could be observed.

Publication types

  • Case Reports

MeSH terms

  • Humans
  • Interferon Type I / therapeutic use*
  • Male
  • Middle Aged
  • Pain
  • Primary Myelofibrosis / complications*
  • Primary Myelofibrosis / drug therapy
  • Primary Myelofibrosis / pathology
  • Primary Myelofibrosis / physiopathology
  • Spleen / pathology
  • Spleen / physiopathology

Substances

  • Interferon Type I