Changing careers: Skin pathogen evolves to infect the bloodstream

Amelia C Stephens; Anthony R Richardson

doi:10.1016/j.chom.2023.01.005

Changing careers: Skin pathogen evolves to infect the bloodstream

Cell Host Microbe. 2023 Feb 8;31(2):166-167. doi: 10.1016/j.chom.2023.01.005.

Authors

Amelia C Stephens¹, Anthony R Richardson²

Affiliations

¹ Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA.
² Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA. Electronic address: anthony.richardson@pitt.edu.

PMID: 36758515
DOI: 10.1016/j.chom.2023.01.005

Abstract

Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) rose to clinical dominance decades ago and predominantly manifested as skin and soft-tissue infections (SSTIs). These clones were distinct from those causing hospital acquired (HA-MRSA) infections. Dyzenhaus et al. describe the evolutionary changes necessary for CA-MRSA clones to cause bloodstream infections (BSIs).

Publication types

Comment

MeSH terms

Anti-Bacterial Agents / therapeutic use
Community-Acquired Infections* / drug therapy
Humans
Methicillin-Resistant Staphylococcus aureus* / genetics
Skin
Soft Tissue Infections* / drug therapy
Staphylococcal Infections* / drug therapy
Staphylococcal Skin Infections* / drug therapy

Substances

Anti-Bacterial Agents