The potential of CD38 protein as a target for autoimmune diseases

Xiaochun Ye; Yongxia Zhao; Wanqing Ma; Irma Ares; Marta Martínez; Bernardo Lopez-Torres; María-Rosa Martínez-Larrañaga; Xu Wang; Arturo Anadón; María-Aránzazu Martínez

doi:10.1016/j.autrev.2023.103289

The potential of CD38 protein as a target for autoimmune diseases

Autoimmun Rev. 2023 Apr;22(4):103289. doi: 10.1016/j.autrev.2023.103289. Epub 2023 Feb 5.

Affiliations

¹ National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei 430070, China; MAO Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Huazhong Agricultural University, Wuhan, Hubei 430070, China.
² National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei 430070, China.
³ Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Universidad Complutense de Madrid (UCM), and Research Institute Hospital 12 de Octubre (i+12). 28040, Madrid, Spain.
⁴ National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei 430070, China; The State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei 430070, China. Electronic address: wangxu@mail.hzau.edu.cn.
⁵ Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Universidad Complutense de Madrid (UCM), and Research Institute Hospital 12 de Octubre (i+12). 28040, Madrid, Spain. Electronic address: aanadon@ucm.es.

PMID: 36750136
DOI: 10.1016/j.autrev.2023.103289

Abstract

Cluster of differentiation 38 (CD38) is a multifunctional cell surface protein involved in nicotinamide adenine dinucleotide (NAD⁺) homeostasis in types of cells and tissues, which can be found in many immune cells and non-immune cells. Previous studies have shown that CD38 plays an important role in regulating innate immunity. Recently, many studies have revealed the importance of CD38 in autoimmune diseases, such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), multiple sclerosis (MS), type 1 diabetes (T1D) and inflammatory bowel disease, among others. In this report, we will briefly discuss the complex immunological functions of CD38 and focus on recent advances in the role of CD38 in the development and pathogenesis of autoimmune diseases, as well as their potential as therapeutic targets for systemic diseases, intending to make a comprehensive understanding of CD38 and its promising therapeutic potential in these systemic diseases.

Keywords: Autoimmune diseases; Autoimmunity; CD38.

Publication types

Letter

MeSH terms

Arthritis, Rheumatoid* / drug therapy
Autoimmune Diseases*
Humans
Immunity, Innate
Lupus Erythematosus, Systemic*
Multiple Sclerosis*

Substances

CD38 protein, human