SnapShot: Clinical and preclinical utility of click chemistry

Sigitas Mikutis; Gonçalo J L Bernardes

doi:10.1016/j.cell.2023.01.018

SnapShot: Clinical and preclinical utility of click chemistry

Cell. 2023 Feb 2;186(3):662-662.e1. doi: 10.1016/j.cell.2023.01.018.

Authors

Sigitas Mikutis¹, Gonçalo J L Bernardes²

Affiliations

¹ Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.
² Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.

PMID: 36736302
DOI: 10.1016/j.cell.2023.01.018

Abstract

Click reactions in a biological setting serve as a way to join two components-for example, a caged prodrug and a decaging agent or a drug and an antibody. Click chemistry has already made several inroads into the clinic with more therapeutic platforms in the making. To view this SnapShot, open or download the PDF.

MeSH terms

Click Chemistry*