Viewing Ca2+-binding sites in the inositol trisphosphate receptor

Olesia Lunko; J Kevin Foskett

doi:10.1016/j.ceca.2023.102697

Viewing Ca²⁺-binding sites in the inositol trisphosphate receptor

Cell Calcium. 2023 Mar:110:102697. doi: 10.1016/j.ceca.2023.102697. Epub 2023 Jan 27.

Authors

Olesia Lunko¹, J Kevin Foskett²

Affiliations

¹ Department of Physiology, Perelman School of Medicine, University of Pennsylvania, 700D Clinical Research Building, 415 Curie Blvd, Philadelphia, PA 19104, USA.
² Department of Physiology, Perelman School of Medicine, University of Pennsylvania, 700D Clinical Research Building, 415 Curie Blvd, Philadelphia, PA 19104, USA. Electronic address: foskett@pennmedicine.upenn.edu.

Abstract

Ca²⁺ is a major ligand of the inositol 1,4,5-trisphosphate receptor (IP₃R) Ca²⁺-release channel. Fan et al. [1] recently solved additional cryo-electron microscopy (cryo-EM) structures of the IP₃R in different ligand-binding states, revealing new Ca²⁺ binding sites.

Keywords: Ca(2+)-release channel; Calcium; Cryo-EM; Inositol trisphosphate receptor; Ion channel; Structure.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Binding Sites
Calcium* / metabolism
Cryoelectron Microscopy
Inositol 1,4,5-Trisphosphate Receptors / metabolism
Inositol 1,4,5-Trisphosphate* / metabolism
Ligands

Substances

Inositol 1,4,5-Trisphosphate Receptors
Ligands
Inositol 1,4,5-Trisphosphate
Calcium

Grants and funding

R35 GM140975/GM/NIGMS NIH HHS/United States