Nagashima-type palmoplantar keratoderma: Case series and two novel variants

Mitchell Braun; Keith A Choate; Erin F Mathes

doi:10.1111/pde.15265

Nagashima-type palmoplantar keratoderma: Case series and two novel variants

Pediatr Dermatol. 2023 Sep-Oct;40(5):882-885. doi: 10.1111/pde.15265. Epub 2023 Jan 31.

Authors

Mitchell Braun¹, Keith A Choate², Erin F Mathes³

Affiliations

¹ University of California San Francisco School of Medicine, San Francisco, California, USA.
² Department of Dermatology, Genetics, and Pathology, Yale University School of Medicine, New Haven, Connecticut, USA.
³ Department of Dermatology, University of California San Francisco, San Francisco, California, USA.

PMID: 36721328
DOI: 10.1111/pde.15265

Abstract

Nagashima-type palmoplantar keratoderma (PPK) is an autosomal recessive PPK. We report four patients, highlight two new genetic variants, and emphasize the possibility of misdiagnosing the condition. Concomitant atopic dermatitis, specifically, may make correct diagnosis challenging. Clinicians should consider the diagnosis of Nagashima-type PPK in patients presenting with mild PPK with transgrediens and understand the importance of individualized multimodal treatment regimens.

Keywords: genetics; inflammatory disorders; keratoderma.

Publication types

Case Reports

MeSH terms

Humans
Keratoderma, Palmoplantar* / diagnosis
Keratoderma, Palmoplantar* / genetics