Severe Mpox Infections in People With Uncontrolled Human Immunodeficiency Virus

Anusha Govind; Susana M Lazarte; Ellen Kitchell; Jeremy Y Chow; Carolee D Estelle; Emma Fixsen; Caitlin Helm; Mamta K Jain; Roma Mehta; Trish M Perl; Jaini M Sutaria; Cristina Thomas; Arturo R Dominguez; Netanya S Utay

doi:10.1093/cid/ciad052

Severe Mpox Infections in People With Uncontrolled Human Immunodeficiency Virus

Clin Infect Dis. 2023 May 24;76(10):1843-1846. doi: 10.1093/cid/ciad052.

Authors

Anusha Govind^{1

2}, Susana M Lazarte^{1

2}, Ellen Kitchell^{1

2}, Jeremy Y Chow^{1

2}, Carolee D Estelle^{1

2}, Emma Fixsen³, Caitlin Helm⁴, Mamta K Jain^{1

2}, Roma Mehta⁵, Trish M Perl^{1

2}, Jaini M Sutaria^{2

6}, Cristina Thomas^{3

4}, Arturo R Dominguez^{3

4}, Netanya S Utay^{1

2}

Affiliations

¹ Division of Infectious Diseases and Geographic Medicine, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
² Parkland Health, Dallas, Texas, USA.
³ Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
⁴ Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
⁵ Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
⁶ Division of Hospital Medicine, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

PMID: 36718662
DOI: 10.1093/cid/ciad052

Abstract

In the current mpox outbreak, infections are usually self-limited. We describe 3 patients with uncontrolled HIV and mpox infections lasting months, causing debilitating lesions, complications, and death, despite initiating anti-mpox and antiretroviral therapy. Delayed treatment of mpox with antiviral agents may contribute to poor outcomes in severely immunocompromised patients.

Keywords: HIV; cytokine storm; death; immunocompromised; mpox.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antiviral Agents / therapeutic use
Disease Outbreaks
HIV Infections* / complications
HIV Infections* / drug therapy
HIV*
Humans
Mpox (monkeypox)* / complications

Substances

Antiviral Agents