[Substances inhibiting amine oxidases. III. Synthesis and amine oxidase inhibition of imidazoquinoline derivatives]

F Chimenti; A Bolasco; S Vomero; M C Casanova; O Befani; S Sabatini; P Turini; B Mondovì; L Gagliardi

[Substances inhibiting amine oxidases. III. Synthesis and amine oxidase inhibition of imidazoquinoline derivatives]

Farmaco Sci. 1987 Jul;42(7):513-24.

[Article in Italian]

Authors

F Chimenti¹, A Bolasco, S Vomero, M C Casanova, O Befani, S Sabatini, P Turini, B Mondovì, L Gagliardi

Affiliation

¹ Istituto di Chimica Farmaceutica e Tossicologica, Università, Sapienza, Roma.

PMID: 3666125

Abstract

The activity of copper and FAD dependent amine oxidases was tested with some derivatives of 3H-imidazo[4,5-h]quinoline and its isomers 3H-imidazo[4,5-f]quinoline, the chemistry of which is described in the literature (1), and Ki calculated. The methyl derivative of 3H-imidazo[4,5-f]quinoline was found to activate the copper bovine serum enzyme, but inhibits the FAD mitochondrial enzyme.

Publication types

English Abstract
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cattle
Chemical Phenomena
Chemistry
Imidazoles / chemical synthesis*
Imidazoles / pharmacology
In Vitro Techniques
Kinetics
Microsomes, Liver / enzymology
Monoamine Oxidase Inhibitors / chemical synthesis*
Monoamine Oxidase Inhibitors / pharmacology
Quinolines / chemical synthesis*
Quinolines / pharmacology
Rats

Substances

Imidazoles
Monoamine Oxidase Inhibitors
Quinolines