miR-124-3p mediates polygenic risk shared between schizophrenia and bipolar disorder

Dariusz Żurawek; Gustavo Turecki

doi:10.1016/j.neuron.2022.12.024

miR-124-3p mediates polygenic risk shared between schizophrenia and bipolar disorder

Neuron. 2023 Jan 18;111(2):144-146. doi: 10.1016/j.neuron.2022.12.024.

Authors

Dariusz Żurawek¹, Gustavo Turecki²

Affiliations

¹ Department of Psychiatry, Douglas Institute, McGill University, 6875 LaSalle Boulevard, Montreal, QC H4H 1R3, Canada.
² Department of Psychiatry, Douglas Institute, McGill University, 6875 LaSalle Boulevard, Montreal, QC H4H 1R3, Canada. Electronic address: gustavo.turecki@mcgill.ca.

PMID: 36657396
DOI: 10.1016/j.neuron.2022.12.024

Abstract

In this issue of Neuron, Namkung et al. demonstrate that the microRNA miR-124-3p is associated with polygenic risk scores shared between schizophrenia and bipolar disorder and confers risk to behavioral alterations common to these two disorders through modulation of AMPA receptor neurotransmission.

Publication types

Comment

MeSH terms

Bipolar Disorder* / genetics
Genetic Predisposition to Disease / genetics
Humans
MicroRNAs* / genetics
Multifactorial Inheritance / genetics
Risk Factors
Schizophrenia* / genetics

Substances

MicroRNAs
MIRN124 microRNA, human