TP53 mutations and variant allele frequency in myelodysplastic syndromes with del(5q): A Mayo-Moffitt study of 156 informative cases

Farah Fleti; Onyee Chan; Amritpal Singh; Maymona G Abdelmagid; Aref Al-Kali; Michelle A Elliott; Kebede H Begna; James M Foran; Talha Badar; Nandita Khera; Najla H Al Ali; Eric Padron; David A Sallman; Mithun Shah; Devendra Hiwase; Animesh Pardanani; Daniel A Arber; Attilio Orazi; Kaaren K Reichard; Rong He; Rhett P Ketterling; Naseema Gangat; Rami Komrokji; Ayalew Tefferi

doi:10.1002/ajh.26845

TP53 mutations and variant allele frequency in myelodysplastic syndromes with del(5q): A Mayo-Moffitt study of 156 informative cases

Am J Hematol. 2023 Apr;98(4):E76-E79. doi: 10.1002/ajh.26845. Epub 2023 Feb 6.

Authors

Farah Fleti^{1

2

3}, Onyee Chan⁴, Amritpal Singh^{1

2

3}, Maymona G Abdelmagid^{1

2

3}, Aref Al-Kali^{1

2

3}, Michelle A Elliott^{1

2

3}, Kebede H Begna^{1

2

3}, James M Foran^{1

2

3}, Talha Badar^{1

2

3}, Nandita Khera^{1

2

3}, Najla H Al Ali⁴, Eric Padron⁴, David A Sallman⁴, Mithun Shah^{1

2

3}, Devendra Hiwase⁵, Animesh Pardanani^{1

2

3}, Daniel A Arber⁶, Attilio Orazi⁷, Kaaren K Reichard^{1

2

3}, Rong He^{1

2

3}, Rhett P Ketterling^{1

2

3}, Naseema Gangat^{1

2

3}, Rami Komrokji⁴, Ayalew Tefferi¹

Affiliations

¹ Mayo Clinic, Rochester, Minnesota, USA.
² Mayo Clinic, Jacksonville, Florida, USA.
³ Mayo Clinic, Scottsdale, Arizona, USA.
⁴ Department of Malignant Hematology, H. Lee Moffitt Cancer Center, Tampa, Florida, USA.
⁵ Division of Blood Cells and Blood Cancer, Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.
⁶ Department of Pathology, University of Chicago, Chicago, Illinois, USA.
⁷ Department of Pathology, Texas Tech University Health Sciences Center, El Paso, Texas, USA.

PMID: 36655582
DOI: 10.1002/ajh.26845

No abstract available

Publication types

Letter

MeSH terms

Chromosome Deletion
Chromosomes, Human, Pair 5 / genetics
Gene Frequency
Humans
Mutation
Myelodysplastic Syndromes* / genetics
Tumor Suppressor Protein p53 / genetics

Substances

TP53 protein, human
Tumor Suppressor Protein p53