Drug-drug interactions with CFTR modulator therapy in cystic fibrosis: Focus on Trikafta®/Kaftrio®

J Cyst Fibros. 2023 May;22(3):478-483. doi: 10.1016/j.jcf.2023.01.005. Epub 2023 Jan 16.

Abstract

The combination of CFTR modulators ivacaftor, tezacaftor and elexacaftor (Trikafta®, Kaftrio®) significantly improve outcomes, including survival in a broad range of cystic fibrosis patients. These drugs have complicated metabolic profiles that make the potential for drug interactions an important consideration for prescribers, care providers and patients. Prolonged survival also increases risk of age-related disease and their associated pharmacotherapy, further increasing the risk of drug interactions and the need for increased vigilance amongst care providers. We systematically searched the literature for studies identifying and evaluating pharmacokinetic and pharmacodynamic drug interactions involving the components of Trikafta®/Kaftrio®. We also searched electronic databases of drugs for possible drug interactions based on metabolic profiles. We identified 86 potential drug interactions of which 13 were supported by 14 studies. There is a significant need for research to describe the likelihood, magnitude and clinical impact of the drug interactions proposed here.

Keywords: CFTR modulator; Cystic fibrosis; Drug interactions; Elexacaftor; Ivacaftor; Pharmacokinetics; Tezacaftor.

Publication types

  • Systematic Review
  • Review

MeSH terms

  • Aminophenols / therapeutic use
  • Benzodioxoles / therapeutic use
  • Cystic Fibrosis Transmembrane Conductance Regulator / genetics
  • Cystic Fibrosis Transmembrane Conductance Regulator / metabolism
  • Cystic Fibrosis* / drug therapy
  • Cystic Fibrosis* / metabolism
  • Drug Combinations
  • Drug Interactions
  • Humans
  • Mutation

Substances

  • elexacaftor, ivacaftor, tezacaftor drug combination
  • Cystic Fibrosis Transmembrane Conductance Regulator
  • Aminophenols
  • Benzodioxoles
  • Drug Combinations
  • CFTR protein, human