Translocation t(6;9)(p22.3;q34) in myelodysplastic syndrome--refractory anemia with excess blasts

Y S Fan; A Raza; J Schumer; S N Sait; A W Block; M Snyderman; A A Sandberg

doi:10.1016/0165-4608(87)90040-9

Translocation t(6;9)(p22.3;q34) in myelodysplastic syndrome--refractory anemia with excess blasts

Cancer Genet Cytogenet. 1987 Nov;29(1):135-8. doi: 10.1016/0165-4608(87)90040-9.

Authors

Y S Fan¹, A Raza, J Schumer, S N Sait, A W Block, M Snyderman, A A Sandberg

Affiliation

¹ Department of Genetics and Endocrinology, Roswell Park Memorial Institute, Buffalo, NY 14263.

PMID: 3664444
DOI: 10.1016/0165-4608(87)90040-9

Abstract

A 69-year-old male patient with refractory anemia with excess blasts (RAEB) was found to have a consistent chromosomal abnormality, t(6;9)(p22.3;q34), in the bone marrow and unstimulated peripheral blood cells. Twenty patients with t(6;9) and leukemia have been reported; some of them had a myelodysplastic syndrome (MDS) before developing overt ANLL. Our patient was still in the MDS stage when the t(6;9) was found. This result suggests that t(6;9) represents one of the pathways from MDS to leukemia in patients with ANLL.

Publication types

Case Reports
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Aged
Anemia, Refractory, with Excess of Blasts / genetics*
Chromosome Banding
Chromosomes, Human, Pair 6*
Chromosomes, Human, Pair 9*
Humans
Karyotyping
Male
Translocation, Genetic*

Grants and funding

CA-41285/CA/NCI NIH HHS/United States