Alternative technique for the injection of fluocinolone acetonide (FAc) intravitreal implant (Iluvien®) in case of leakage of its injector

Eur J Ophthalmol. 2023 May;33(3):1501-1505. doi: 10.1177/11206721221151136. Epub 2023 Jan 11.

Abstract

Purpose: To show an alternative surgical technique for the introduction of the intravitreal fluocinolone acetonide (FAc) implant (Iluvien®) into the vitreous cavity using a 23-gauge (G) trocar if it is retained during its implantation in the subconjunctival space.

Methods: We describe the surgical procedure performed to solve the complication: The FAc implant was extracted from the subconjunctival space using flat retinal forceps. A 23-G trocar was inserted 3,5 mm to the limbus. The same flat retinal forceps were used to take the FAc implant and introduce it into the vitreous cavity using a 23-G trocar.

Results: The patient's best corrected visual acuity (BCVA) (Snellen) improved from 20/200 to 20/63 and the central macular thickness (CMT) was reduced from 610 microns (µm) to 215 µm after one week of the FAc implantation. He remained stable after 3 months of follow-up, with a BCVA of 20/63 and a CMT of 191 µm. His intraocular pressure (IOP) remained stable and the integrity of the implant was checked by indirect ophthalmoscopy.

Conclusion: The introduction of the intravitreal FAc implant using a 23-gauge trocar constitutes a valid alternative if it is retained during its implantation in the subconjunctival space.The functionality of the implant remained intact in our patient.

Keywords: Alternative technique; Iluvien; cystoid macular edema; fluocinolone implant; intravitreal implant; surgical technique.

MeSH terms

  • Diabetic Retinopathy* / drug therapy
  • Drug Implants / therapeutic use
  • Fluocinolone Acetonide / therapeutic use
  • Glucocorticoids / therapeutic use
  • Humans
  • Intravitreal Injections
  • Macular Edema* / drug therapy
  • Macular Edema* / etiology
  • Male

Substances

  • Fluocinolone Acetonide
  • Glucocorticoids
  • Drug Implants