We previously described the hypotheses, outcomes, design, and analysis for E2C2, a pragmatic stepped-wedge trial to assess an intervention to improve symptom control in patients with cancer. Subsequent consideration of the design and cohort led to the addition of a second primary hypothesis. This article describes and presents the rationale for this second hypothesis. This addendum also details a revised analytic approach, necessitated by inconsistencies in the original analytic plan. The design, outcomes, and other aspects of the protocol remain unchanged.
Keywords: Electronic health record; Neoplasm; Pain; Palliative care; Patient care team; Patient-reported outcome measure; Quality of life; Self-management; Survivor; Systems integration.
© 2023. The Author(s).