Multiplexing mRNAs builds a "broad-immunity wall" against the flu

Sci Immunol. 2023 Jan 6;8(79):eadg4686. doi: 10.1126/sciimmunol.adg4686. Epub 2023 Jan 6.

Authors

Nicholas J Catanzaro¹, David R Martinez¹

Affiliation

¹ University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

PMID: 36608110
DOI: 10.1126/sciimmunol.adg4686

Abstract

Delivery of mRNAs encoding influenza HA antigens covering all known subtypes and lineages elicits cross-reactive and protective immunity.

Publication types

Comment

MeSH terms

Antibodies, Viral
Cross Reactions
Hemagglutinin Glycoproteins, Influenza Virus
Humans
Influenza, Human*
Orthomyxoviridae Infections*

Substances

Antibodies, Viral
Hemagglutinin Glycoproteins, Influenza Virus