NRAS Gene Mutation in Differentiated High-Grade Thyroid Carcinoma With Multiphenotypic Metastatic Pattern: A Case Report

Juan C Alvarez Moreno; Palawinnage Muthukumarana; Suimin Qiu

doi:10.7759/cureus.32177

NRAS Gene Mutation in Differentiated High-Grade Thyroid Carcinoma With Multiphenotypic Metastatic Pattern: A Case Report

Cureus. 2022 Dec 4;14(12):e32177. doi: 10.7759/cureus.32177. eCollection 2022 Dec.

Authors

Juan C Alvarez Moreno¹, Palawinnage Muthukumarana², Suimin Qiu¹

Affiliations

¹ Pathology, University of Texas Medical Branch, Galveston, USA.
² Pathology and Laboratory Medicine, University of Texas Medical Branch, Galveston, USA.

Abstract

Differentiated high-grade thyroid carcinoma (DHGTC) has a high mitotic count (≥5 mitoses per 2mm²) and/or tumor necrosis without anaplastic features. These tumors are rare, and the prevalence is not yet established among thyroid malignancies. BRAF andRAS mutations are the main driver mutations in these tumors. We present a case of a 43-year-old woman with DHGTC and NRASmutation, presenting with metastatic follicular component to the bone and papillary component to lymph nodes.

Keywords: bone metastasis; follicular carcinoma of the thyroid; lymph node metastasis; nras; papillary carcinoma of thyroid; thyroid pathology.

Publication types

Case Reports