DKK1 is a strong candidate for mesiodens and taurodontism

Piranit Kantaputra; Peeranat Jatooratthawichot; Naomi Kottege; Robert P Anthonappa; Massupa Kaewgahya; Sissades Tongsima; Chumpol Ngamphiw; James R Ketudat Cairns; Danilo Predes; Xi He

doi:10.1111/cge.14295

DKK1 is a strong candidate for mesiodens and taurodontism

Clin Genet. 2023 Jun;103(6):714-716. doi: 10.1111/cge.14295. Epub 2023 Jan 13.

Authors

Affiliations

¹ Center of Excellence in Medical Genetics Research, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand.
² Division of Pediatric Dentistry, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand.
³ School of Chemistry, Institute of Science, and Center for Biomolecular Structure, Function and Application, Suranaree University of Technology, Nakhon Ratchasima, Thailand.
⁴ Department of Pediatric Dentistry, University of Western Australia Dental School, Nedlands, Western Australia, Australia.
⁵ National Biobank of Thailand, National Science and Technology Development Agency,Thailand Science Park, Pathum Thani, Thailand.
⁶ F. M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Abstract

A mutation in DKK1 gene leads to inhibitory DKK1 function, over-activation of WNT/β-catenin signaling, disruptive development of dental epithelium, and subsequent mesiodens formation.

Keywords: WNT signaling; mesiodens; supernumerary tooth; taurodontism.

Publication types

Letter
Research Support, N.I.H., Extramural

MeSH terms

Dental Pulp Cavity / abnormalities
Humans
Intercellular Signaling Peptides and Proteins
Tooth Abnormalities*
Wnt Signaling Pathway
beta Catenin

DKK1 is a strong candidate for mesiodens and taurodontism

Authors

Affiliations

Abstract

Publication types

MeSH terms

Substances

Supplementary concepts

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