Intra-articular nanodrug delivery strategies for treating osteoarthritis

Dongyang Zhou; Fengjin Zhou; Shihao Sheng; Yan Wei; Xiao Chen; Jiacan Su

doi:10.1016/j.drudis.2022.103482

Intra-articular nanodrug delivery strategies for treating osteoarthritis

Drug Discov Today. 2023 Mar;28(3):103482. doi: 10.1016/j.drudis.2022.103482. Epub 2022 Dec 27.

Authors

Dongyang Zhou¹, Fengjin Zhou², Shihao Sheng³, Yan Wei⁴, Xiao Chen⁵, Jiacan Su⁶

Affiliations

¹ Institute of Translational Medicine, Shanghai University, Shanghai 200444, China; Institute of Advanced Interdisciplinary Materials Science, Shanghai University, Shanghai 200444, China; College of Medicine, Shanghai University, Shanghai 200444, China; Organoid Research Center, Shanghai University, Shanghai 200444, China.
² Department of Orthopaedics, Honghui Hospital, Xi'an Jiao Tong University, Xi'an 710000, China.
³ Department of Trauma Orthopedics, Changhai Hospital, Naval Medical University, Shanghai 200433, China.
⁴ Institute of Translational Medicine, Shanghai University, Shanghai 200444, China; Organoid Research Center, Shanghai University, Shanghai 200444, China. Electronic address: ywei@shu.edu.cn.
⁵ Department of Trauma Orthopedics, Changhai Hospital, Naval Medical University, Shanghai 200433, China. Electronic address: sirchenxiao@126.com.
⁶ Institute of Translational Medicine, Shanghai University, Shanghai 200444, China; Institute of Advanced Interdisciplinary Materials Science, Shanghai University, Shanghai 200444, China; Organoid Research Center, Shanghai University, Shanghai 200444, China; Department of Trauma Orthopedics, Changhai Hospital, Naval Medical University, Shanghai 200433, China. Electronic address: Drsujiacan@163.com.

PMID: 36584875
DOI: 10.1016/j.drudis.2022.103482

Abstract

Osteoarthritis (OA) is characterized by progressive cartilage degeneration. Pharmaceutical intervention remains a main treatment approach. However, drug delivery via intra-articular administration (IA) can be restricted by rapid clearance, the dense and highly negatively charged extracellular matrix (ECM) of cartilage, and uneven distribution of diseased chondrocytes. Nanodrug delivery systems, such as liposomes, micelles, and nanoparticles (NPs), have shown great potential to prolong intra-articular residence, penetrate the ECM, and achieve diseased chondrocyte-specific delivery. In this review, we discuss the challenges associated with intra-articular drug delivery in OA and the nanodrug delivery strategies developed to overcome these challenges. It is anticipated that these nanodrug delivery strategies will advance IA of drugs into broader applications in OA treatment.

Keywords: Intra-articular administration; Nanodrug delivery strategies; Osteoarthritis.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Cartilage
Cartilage, Articular*
Chondrocytes
Humans
Injections, Intra-Articular
Nanoparticles* / therapeutic use
Osteoarthritis* / drug therapy