Targeted lung denervation modulates the mucosal epithelial transcriptome in COPD

Karthi Srikanthan; Loes Kistemaker; Dirk-Jan Slebos; Wolfgang Gesierich; Kaid Darwiche; Peter Bonta; Gaetan Deslee; Pallav Shah; Reinoud Gosens

doi:10.1183/23120541.00146-2022

Targeted lung denervation modulates the mucosal epithelial transcriptome in COPD

ERJ Open Res. 2022 Dec 27;8(4):00146-2022. doi: 10.1183/23120541.00146-2022. eCollection 2022 Oct.

Authors

Karthi Srikanthan¹, Loes Kistemaker², Dirk-Jan Slebos³, Wolfgang Gesierich⁴, Kaid Darwiche⁵, Peter Bonta⁶, Gaetan Deslee⁷, Pallav Shah^{1

8}, Reinoud Gosens^{9

8}

Affiliations

¹ Royal Brompton and Harefield NHS Foundation Trust, National Heart and Lung Institute, Imperial College, London, UK.
² Aquilo BV, Groningen, The Netherlands.
³ University Medical Center Groningen, Groningen, The Netherlands.
⁴ Asklepios-Fachkliniken Munchen Gauting, Gauting, Germany.
⁵ Department for Interventional Pneumology, Ruhrlandklinik - University Medicine, Essen, Germany.
⁶ Academic Medical Centre, Amsterdam, The Netherlands.
⁷ Department of Pulmonary Medicine, INSERM UMRS 1250, CHU of Reims, Reims, France.
⁸ These authors contributed equally.
⁹ Department of Molecular Pharmacology, University of Groningen, Groningen, The Netherlands.

Abstract

This study shows that TLD reduces airway epithelial expression of genes related to acetylcholine processing and airway inflammation, which may help to elucidate the mechanism for its effect of reducing severe exacerbations in COPD https://bit.ly/3dWcqZk.