The brain stimulation of DLPFC regulates choice preference in intertemporal choice self-other differences

Abstract

Intertemporal choice requires to make decision by evaluating the value of two options consisting of different times and benefits. The dorsolateral prefrontal cortex (DLPFC) is a key brain region for modulating intertemporal choice. The aim of this study is to investigate the effect of non-invasive brain stimulation over DLPFC on intertemporal choice behavior for self and others. We used transcranial direct current stimulation (tDCS) and continuous theta burst stimulation (cTBS) to stimulate bilateral DLPFC in two experiments respectively. After stimulation, subjects made a choice between a Smaller-Sooner (SS) reward and a Larger-Later (LL) reward in intertemporal choice task. The results showed that cTBS stimulation on the left DLPFC reduced the choice preference for SS reward when individuals made choices for themselves. The cTBS stimulation caused preference difference between choosing for self and parents. But tDCS stimulation had no effect on regulating choice preference. In addition, subjects preferred SS reward for self than strangers. Time-types and monetary difference of rewards affected the choice preference. The presence of immediate time increased the choice preference of SS reward. As the monetary difference increased, the choice proportion of SS reward decreased. Our study demonstrates that brain stimulation on the left DLPFC can regulate choice preference behavior in intertemporal choice.

Keywords: Continuous theta burst stimulation (cTBS); Dorsolateral prefrontal cortex (DLPFC); Intertemporal choice; Self-other differences; Transcranial direct current stimulation (tDCS).