To investigate the expression of small dense low-density lipoprotein cholesterol (sdLDL-C) in patients with H-type hypertension and its association with H-type hypertension and methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms. The retrospective study method was used,and a total of 207 hospitalized hypertensive patients (76 males and 131 females, aged 40-82 years, median age 66 years) admitted to the Zibo First Hospital from March 2021 to March 2022 were enrolled in this study. The levels of homocysteine (Hcy), sdLDL-C, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), triglyceride (TG) and lipoprotein (a) [Lp(a)] were measured. The patients were divided into H-type hypertensive group (n=105, 40 males and 65 females) and non-H-type hypertensive group (n=102, 36 males and 66 females) according to Hcy levels. The C677T polymorphism of methylenetetrahydrofolate reductase (MTHFR) gene was detected in each group. Logistic regression analysis was performed for the related factors of H-type hypertension. The serum sdLDL-C levels were (0.92±0.31) and (0.65±0.28) mmol/L in H-type hypertension group and non-H-type hypertension group, respectively. The sdLDL-C levels in H-type hypertension group were significantly higher than those in non-H-type hypertension group (t=6.500, P<0.01). There was no significant difference in the serum sdLDL-C levels between males and females in H-type hypertension group (t=-1.543, P=0.129). The CC, CT, TT genotypes and C and T allele frequencies of MTHFR C677T in H-type hypertension group were significantly different from those in non-H-type hypertension group (P<0.05). The Hcy and sdLDL-C levels in different genotypes of MTHFR in H-type hypertension group were significantly different (H=12.742, P=0.002; F=3.345, P=0.042). Among them, Hcy levels were higher in TT genotype than in CT and CC genotypes, respectively (Z=-28.099, P=0.003; Z=-16.112, P=0.040), and sdLDL-C levels were higher in TT genotype than in CC genotype (t=-2.587, P=0.012). Logistic regression analysis showed that age, sdLDL-C, and MTHFRC677T TT genotypes were associated with the development for H-type hypertension. In conclusion, the level of sdLDL-C is associated with MTHFR gene polymorphisms and may be associated with the development of H-type hypertension.
探讨小而密低密度脂蛋白胆固醇（sdLDL-C）在H型高血压患者中的表达及其与H型高血压和亚甲基四氢叶酸还原酶（MTHFR）基因多态性间的相关性。采用回顾性研究，选择2021年3月至2022年3月在山东省淄博市第一医院诊治的207例住院高血压患者，男76例，女131例，年龄40~82岁、中位数年龄66岁。检测同型半胱氨酸（Hcy）、sdLDL-C、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、总胆固醇（TC）、甘油三酯（TG）、脂蛋白（a）［Lp（a）］水平。根据Hcy水平分为H型高血压组（105例，男性40例，女性65例）和非H型高血压组（102例，男性36例，女性66例），检测各组MTHFR C677T多态性，对H型高血压发生相关因素进行logistic回归分析。结果显示，H型高血压组和非H型高血压组血清sdLDL-C水平分别为（0.92±0.31）mmol/L和（0.65±0.28）mmol/L，H型高血压组sdLDL-C水平显著高于非H型高血压组（t=6.500，P<0.01），H型高血压组男性和女性的血清sdLDL-C水平差异无统计学意义（t=-1.543，P=0.129）；H型高血压组MTHFR C677T的CC、CT、TT基因型和C、T等位基因频率与非H型高血压组相比差异有统计学意义（P<0.05）；H型高血压组MTHFR 不同基因型间Hcy和sdLDL-C水平差异有统计学意义（H=12.742，P=0.002；F=3.345，P=0.042）。其中H型高血压组TT基因型Hcy水平分别高于CC、CT基因型（Z=-28.099，P=0.003；Z=-16.112，P=0.040），TT基因型sdLDL-C水平高于CC基因型（t=-2.587，P=0.012）。logistic回归分析结果显示年龄、sdLDL-C和MTHFR C677T TT基因型与H型高血压发生有关。综上，sdLDL-C水平与MTHFR基因多态性及H型高血压发生可能有相关性。.