Primary structure of alpha-bungarotoxin. Six amino acid residues differ from the previously reported sequence

M Ohta; K Ohta; H Nishitani; K Hayashi

doi:10.1016/0014-5793(87)80195-3

Primary structure of alpha-bungarotoxin. Six amino acid residues differ from the previously reported sequence

FEBS Lett. 1987 Sep 28;222(1):79-82. doi: 10.1016/0014-5793(87)80195-3.

Authors

M Ohta¹, K Ohta, H Nishitani, K Hayashi

Affiliation

¹ Department of Biochemistry, Utano National Hospital, Kyoto, Japan.

PMID: 3653402
DOI: 10.1016/0014-5793(87)80195-3

Abstract

alpha-Bungarotoxin (alpha-BuTx) was isolated from the venom of the Formosan banded krait (Bungarus multicinctus). The amino acid sequence was determined by a combination of conventional methods. In contrast to the sequence of alpha-BuTx reported by Mebs et al. ([1971) Biochem. Biophys. Res. Commun. 44, 711-716], our results revealed the presence of Ser-Pro-Ile, Pro-His and Gln-Arg at positions 9-11, 67-68 and 71-72 from the amino-terminal, respectively, and not Ile-Pro-Ser, His-Pro and Arg-Gln as reported previously.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Bungarotoxins* / isolation & purification
Peptide Fragments / analysis

Substances

Bungarotoxins
Peptide Fragments