MUC4 and MMP7 in saliva and gingival crevicular fluid (GCF) in adolescents at West Bengal, India

Sayan Chattopadhyay; Rachita Arora; Amit Kishor; Shivani Singh; Abhijeet Alok; Mainak Mitra

doi:10.6026/97320630018165

MUC4 and MMP7 in saliva and gingival crevicular fluid (GCF) in adolescents at West Bengal, India

Bioinformation. 2022 Mar 31;18(3):165-169. doi: 10.6026/97320630018165. eCollection 2022.

Authors

Sayan Chattopadhyay¹, Rachita Arora¹, Amit Kishor², Shivani Singh³, Abhijeet Alok⁴, Mainak Mitra¹

Affiliations

¹ Burdwan Dental College and Hospital, West Bengal, India.
² Primary Health Centre Baniyapur, Chapra, Bihar, India.
³ Dr B R Ambedkar Institute of Dental Sciences and Hospital, Patna, Bihar, India.
⁴ Primary Health Centre, Khaira, Jamui, Bihar, India.

Abstract

Mucin 4 (MUC4) and matrix metalloproteinase 7 (MMP7) have been reported to be associated with chronic periodontitis as seen in gingival tissue biopsies. Therefore, it is of interest to estimate the levels of MUC4 and MMP7 in saliva and gingival crevicular fluid (GCF) samples of periodontitis in adolescents patients at West Bengal, India. MUC4 levels were significantly lower in saliva and GCF from periodontitis patients compared to healthy controls. However, MMP7 levels were found to be significantly higher in saliva and GCF from periodontitis patients. Thus, MUC4 and MMP7 are biomarkers for periodontitis diagnosis and towards further consideration.

Keywords: Gingival Crevicular Fluid (GCF); matrix metalloproteinase 7(MMP7); mucin 4(MUC4); periodontitis; saliva.