Changing times: The impact of gram-negative breakpoint changes over the previous decade

Wes M Johnson; Justin A Clark; Katherine Olney; Donna R Burgess; David S Burgess

doi:10.1017/ash.2022.301

Changing times: The impact of gram-negative breakpoint changes over the previous decade

Antimicrob Steward Healthc Epidemiol. 2022 Oct 7;2(1):e165. doi: 10.1017/ash.2022.301. eCollection 2022.

Authors

Wes M Johnson¹, Justin A Clark², Katherine Olney¹, Donna R Burgess^{1

2}, David S Burgess²

Affiliations

¹ University of Kentucky Chandler Medical Center, Lexington, Kentucky.
² University of Kentucky College of Pharmacy, Lexington, Kentucky.

Abstract

We assessed breakpoint changes of 13,101 Enterobacterales and Pseudomonas aeruginosa isolates from the past decade. All β-lactams and fluoroquinolones demonstrated decreased susceptibilities following breakpoint changes. Enterobacter cloacae experienced the largest average decrease in susceptibility amongst the Enterobacterales at 5.3% and P. aeruginosa experienced an average decrease in susceptibility of 9.3%.