Noradrenergic modulation of stress resilience

Xiaojing Zhai; Dongyu Zhou; Yi Han; Ming-Hu Han; Hongxing Zhang

doi:10.1016/j.phrs.2022.106598

Noradrenergic modulation of stress resilience

Pharmacol Res. 2023 Jan:187:106598. doi: 10.1016/j.phrs.2022.106598. Epub 2022 Dec 5.

Authors

Xiaojing Zhai¹, Dongyu Zhou¹, Yi Han¹, Ming-Hu Han², Hongxing Zhang³

Affiliations

¹ Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China; Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China; NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China.
² Department of Mental Health and Public Health, Faculty of Life and Health Sciences, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Guangdong 518055, China; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: ming-hu.han@mssm.edu.
³ Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China; Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China; NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China. Electronic address: hongxing.zhang@xzhmu.edu.cn.

PMID: 36481260
DOI: 10.1016/j.phrs.2022.106598

Abstract

Resilience represents an active adaption process in the face of adversity, trauma, tragedy, threats, or significant sources of stress. Investigations of neurobiological mechanisms of resilience opens an innovative direction for preclinical research and drug development for various stress-related disorders. The locus coeruleus norepinephrine system has been implicated in mediating stress susceptibility versus resilience. It has attracted increasing attention over the past decades with the revolution of modern neuroscience technologies. In this review article, we first briefly go over resilience-related concepts and introduce rodent paradigms for segregation of susceptibility and resilience, then highlight recent literature that identifies the neuronal and molecular substrates of active resilience in the locus coeruleus, and discuss possible future directions for resilience investigations.

Keywords: Antidepressant; DK-AH269 (PubChem CID: 132989); Fluoxetine (PubChem CID: 3386); Idazoxan (PubChem CID: 54459); Locus coeruleus; Molecular mechanisms; Neural circuit; Norepinephrine; Resilience; Retigabine (PubChem CID: 121892); Spravato (PubChem CID: 182137); ZD7288 (PubChem CID: 123983); Zulresso (PubChem CID: 92786).

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Norepinephrine*

Substances

Norepinephrine