Structures and mechanism of chitin synthase and its inhibition by antifungal drug Nikkomycin Z

Cell Discov. 2022 Dec 6;8(1):129. doi: 10.1038/s41421-022-00495-y.

Yanan Wu^#^{1

2}, Min Zhang^#^{1

2}, Yizheng Yang^#¹, Xuyang Ding¹, Ping Yang¹, Kai Huang^{3

4}, Xinlin Hu¹, Mingjie Zhang^{5

6}, Xiaotian Liu⁷, Hongjun Yu^{8

9}

¹ Department of Biochemistry and Molecular Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
² Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
³ Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
⁴ Clinical Center of Human Gene Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
⁵ School of Life Sciences, Southern University of Science and Technology, Shenzhen, Guangdong, China.
⁶ Greater Bay Biomedical Innocenter, Shenzhen Bay Laboratory, Shenzhen, Guangdong, China.
⁷ School of Life Sciences, Southern University of Science and Technology, Shenzhen, Guangdong, China. liuxt@sustech.edu.cn.
⁸ Department of Biochemistry and Molecular Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. hongjun_yu@hust.edu.cn.
⁹ Cell Architecture Research Center, Huazhong University of Science and Technology, Wuhan, Hubei, China. hongjun_yu@hust.edu.cn.

^# Contributed equally.

No abstract available

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