Evaluation of hydroxamate-based resins towards a more clinically viable 44Ti/44Sc radionuclide generator

Leah Gajecki; Celine M Marino; Cathy S Cutler; Vanessa A Sanders

doi:10.1016/j.apradiso.2022.110588

Evaluation of hydroxamate-based resins towards a more clinically viable ⁴⁴Ti/⁴⁴Sc radionuclide generator

Appl Radiat Isot. 2023 Feb:192:110588. doi: 10.1016/j.apradiso.2022.110588. Epub 2022 Nov 29.

Authors

Leah Gajecki¹, Celine M Marino², Cathy S Cutler³, Vanessa A Sanders³

Affiliations

¹ Collider Accelerator Department, Brookhaven National Laboratory, Upton, NY, 11973, USA. Electronic address: lgajecki@bnl.gov.
² Collider Accelerator Department, Brookhaven National Laboratory, Upton, NY, 11973, USA; Chemistry Department, Stony Brook University, Stony Brook, NY, 11794, USA.
³ Collider Accelerator Department, Brookhaven National Laboratory, Upton, NY, 11973, USA.

PMID: 36470155
DOI: 10.1016/j.apradiso.2022.110588

Abstract

Several hydroxamate-based resins were synthesized and tested for use in ⁴⁴Ti/⁴⁴Sc generator systems in small scale experiments (740 kBq ⁴⁴Ti). The most promising resin was tested further in larger scale generator studies (37 MBq). This resin displayed impressive retention of ⁴⁴Ti over several elutions, and high quantities of ⁴⁴Sc were obtained in small volumes of dilute HCl eluents. Initial radiolabeling experiments were conducted and demonstrated the possibility of direct radiolabeling of the generator produced ⁴⁴Sc with DOTA.

Published by Elsevier Ltd.

MeSH terms

Hydroxamic Acids
Radioisotopes*
Radionuclide Generators*
Radiopharmaceuticals
Scandium
Titanium

Substances

Radioisotopes
Titanium
Scandium
Radiopharmaceuticals
Hydroxamic Acids