Autoimmune Hepatitis Following mRNA COVID-19 Vaccination in a Very Old Patient With Preexisting Sjögren's Syndrome: A Case Report

Yukinari Yoshida; Norikazu Iwata; Yoshifumi Ishii; Yuji Hinoda; Takao Endo

doi:10.7759/cureus.30896

Autoimmune Hepatitis Following mRNA COVID-19 Vaccination in a Very Old Patient With Preexisting Sjögren's Syndrome: A Case Report

Cureus. 2022 Oct 31;14(10):e30896. doi: 10.7759/cureus.30896. eCollection 2022 Oct.

Authors

Yukinari Yoshida¹, Norikazu Iwata¹, Yoshifumi Ishii², Yuji Hinoda¹, Takao Endo¹

Affiliations

¹ Department of Internal Medicine and Gastroenterology, Sapporo Shirakabadai Hospital, Sapporo, JPN.
² Department of Pathology, Sapporo Shirakabadai Hospital, Sapporo, JPN.

Abstract

A case of autoimmune hepatitis (AIH) following COVID-19 vaccination in a very old patient is presented. An 85-year-old woman who had preexisting Sjögren's syndrome (SS) but had never shown evidence of liver disease was admitted to our hospital due to jaundice and liver dysfunction. Further laboratory tests, imaging studies, and liver histology proved this to be a case of definite AIH. Eight weeks before the disease onset, she had received the second dose of mRNA COVID-19 vaccination. To our knowledge, this is the first case of AIH following COVID-19 vaccination in a patient with a history of SS.

Keywords: autoimmune hepatitis; mrna covid-19 vaccine; sars-cov-2; sjögren’s syndrome; very old patient.

Publication types

Case Reports