Low-grade B-cell lymphoma of the central nervous system with plasmacytic differentiation and amyloid deposition

Gianluca Lopez; Karam Han; Shino D Magaki; Sophie X Song; Noriko Salamon; Kanwarpal S Kahlon; Inna Keselman; Ausaf A Bari; Harry V Vinters

doi:10.1111/neup.12886

Low-grade B-cell lymphoma of the central nervous system with plasmacytic differentiation and amyloid deposition

Neuropathology. 2023 Aug;43(4):313-318. doi: 10.1111/neup.12886. Epub 2022 Nov 30.

Authors

Gianluca Lopez^{1

2}, Karam Han², Shino D Magaki², Sophie X Song³, Noriko Salamon⁴, Kanwarpal S Kahlon⁵, Inna Keselman⁶, Ausaf A Bari⁷, Harry V Vinters^{2

6}

Affiliations

¹ University of Milan, Milan, Italy.
² Neuropathology, Department of Pathology and Laboratory Medicine, Ronald Reagan UCLA Medical Center and David Geffen School of Medicine, University of California, Los Angeles, California, USA.
³ Hematopathology, Department of Pathology and Laboratory Medicine, Ronald Reagan UCLA Medical Center and David Geffen School of Medicine, University of California, Los Angeles, California, USA.
⁴ Department of Radiology, Ronald Reagan UCLA Medical Center and David Geffen School of Medicine, University of California, Los Angeles, California, USA.
⁵ Division of Hematology-Oncology, Ronald Reagan UCLA Medical Center and David Geffen School of Medicine, University of California, Los Angeles, California, USA.
⁶ Department of Neurology, Ronald Reagan UCLA Medical Center and David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
⁷ Department of Neurosurgery, Ronald Reagan UCLA Medical Center and David Geffen School of Medicine, University of California, Los Angeles, California, USA.

PMID: 36451532
DOI: 10.1111/neup.12886

Abstract

A 65-year-old woman with a resolved history of epilepsy due to a motor vehicle accident and hippocampal sclerosis presented with recurrent de novo seizures. Brain imaging demonstrated enhancement in the left parieto-occipital lobe. At histopathological examination, the lesion displayed a diffuse lymphoid infiltrate comprised of small atypical lymphocytes, plasmacytoid lymphocytes, and scattered plasma cells with amyloid deposition. Pathology workup demonstrated a monotypic B-cell phenotype of the lymphoid infiltrate, expressing lambda light chain restriction and plasmacytic differentiation without MYD88 mutations. The patient had no systemic evidence of lymphoma, plasma cell dyscrasia, or amyloidosis. A diagnosis of low-grade B-cell lymphoma of the central nervous system with plasmacytic differentiation and amyloid deposition was made.

Keywords: amyloid; brain; central nervous system; lymphoma; meninges.

Publication types

Case Reports

MeSH terms

Amyloidosis*
Brain / pathology
Cell Differentiation
Humans
Lymphoma, B-Cell*