Microbiome in Anxiety and Other Psychiatric Disorders

Norman M Spivak; Jonathan Haroon; Andrew Swenson; Scott A Turnbull; Nolan Dang; Matthew Ganeles; Collin Price; Margaret Distler; Erika Nurmi; Helen Lavretsky; Alexander Bystritsky

doi:10.1016/j.mcna.2022.08.010

Microbiome in Anxiety and Other Psychiatric Disorders

Med Clin North Am. 2023 Jan;107(1):73-83. doi: 10.1016/j.mcna.2022.08.010. Epub 2022 Oct 28.

Affiliations

¹ UCLA-Caltech Medical Scientist Training Program; Department of Psychiatry and Biobehavioral Sciences, DGSOM, UCLA, 300 UCLA Medical Plaza, Suite 2200, Los Angeles, CA 90095, USA. Electronic address: nspivak@mednet.ucla.edu.
² Department of Psychiatry and Biobehavioral Sciences, DGSOM, UCLA, 300 UCLA Medical Plaza, Suite 2200, Los Angeles, CA 90095, USA.
³ Department of Internal Medicine, Kirk Kerkorian SOM, UNLV, 4505 South Maryland Parkway, Las Vegas, NV 89154, USA.
⁴ Department of Molecular, Cell and Developmental Biology, UCLA, 300 UCLA Medical Plaza, Suite 2200, Los Angeles, CA 90095, USA.

PMID: 36402501
DOI: 10.1016/j.mcna.2022.08.010

Abstract

Initial studies suggested that the fluctuations in the quantity, variety, and composition of the gut microbiota can significantly affect disease processes. This change in the gut microbiota causing negative health benefits was coined dysbiosis. Initial research focused on gastrointestinal illnesses. However, the gut microbiome was found to affect more than just gastrointestinal diseases. Numerous studies have proven that the gut microbiome can influence neuropsychiatric diseases such as Parkinson's disease, Alzheimer's disease, and multiple sclerosis.

Keywords: Anxiety; Gut–brain axis; Microbiome; PANS.

Publication types

Review

MeSH terms

Anxiety
Anxiety Disorders
Gastrointestinal Microbiome*
Humans
Mental Disorders*
Microbiota*