Restored biosynthetic pathways induced by MSCs serve as rescue mechanism in leukemia cells after L-asparaginase therapy

Blood Adv. 2023 May 23;7(10):2228-2236. doi: 10.1182/bloodadvances.2021006431.

Natividad Alquezar-Artieda^{1

2}, Daniela Kuzilkova^{1

2

3}, Jennie Roberts⁴, Katerina Hlozkova^{1

2}, Alena Pecinova⁵, Petr Pecina⁵, Martina Zwyrtkova^{1

2}, Eliska Potuckova^{1

2}, Daniel Kavan⁶, Ivana Hermanova^{1

2}, Marketa Zaliova^{1

2

3}, Petr Novak⁶, Tomas Mracek⁵, Lucie Sramkova^{2

3}, Daniel A Tennant⁴, Jan Trka^{1

2

3}, Julia Starkova^{1

2

3}

¹ Childhood Leukaemia Investigation Prague, Prague, Czech Republic.
² Second Faculty of Medicine, Department of Pediatric Hematology and Oncology, Charles University, Prague, Czech Republic.
³ University Hospital Motol, Prague, Czech Republic.
⁴ Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom.
⁵ Department of Bioenergetics, Institute of Physiology of the Czech Academy of Science, Prague, Czech Republic.
⁶ Laboratory of Structural Biology and Cell Signalling, Institute of Microbiology, Academy of Science of the Czech Republic, Prague, Czech Republic.

No abstract available

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