Fe-catalyzed hydroxytrifluoromethylation of α-(trifluoromethyl)styrenes with CF3SO2Na: facile access to α,β-bistrifluoromethyl tertiary alcohols

Abstract

A mild and practical Fe-catalyzed hydroxytrifluoromethylation of α-(trifluoromethyl)styrenes with CF₃SO₂Na in the presence of K₂S₂O₈ and air was developed. The reaction proceeded efficiently at room temperature without β-fluoride elimination and afforded the corresponding α,β-bistrifluoromethyl tertiary alcohols in good to excellent yields.