MR1: An unconventional twist in the tail

J Cell Biol. 2022 Dec 5;221(12):e202211016. doi: 10.1083/jcb.202211016. Epub 2022 Nov 14.

Abstract

MR1 is a conserved molecule that binds microbial vitamin B metabolites and presents them to unconventional T cells. Lim and colleagues (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202110125) uncover the role of AP2 in ensuring MR1 surface presentation, which relies on an atypical motif within the MR1 cytoplasmic tail.

Publication types

  • Comment

MeSH terms

  • Adaptor Protein Complex 2* / metabolism
  • Antigen Presentation*
  • Histocompatibility Antigens Class I* / metabolism
  • Humans
  • Minor Histocompatibility Antigens* / metabolism
  • T-Lymphocytes
  • Vitamin B Complex / metabolism

Substances

  • Histocompatibility Antigens Class I
  • Minor Histocompatibility Antigens
  • MR1 protein, human
  • Vitamin B Complex
  • Adaptor Protein Complex 2