Consensus guide on prophylactic gonadectomy in different sex development

Abstract

The risk of suffering from gonadal germ cell tumors (GCT) is increased in some patients with different sexual development (DSD), mainly in those with Y chromosome material. This risk, however, varies considerably depending on a multitude of factors that make the decision for prophylactic gonadectomy extremely difficult. In order to make informed recommendations on the convenience of this procedure in cases where there is potential for malignancy, this consensus guide evaluates the latest clinical evidence, which is generally low, and updates the existing knowledge in this field.

Keywords: Anomalías de la diferenciación sexual; Desarrollo sexual diferente; Disorders of sex development; Germ cell neoplasia in situ; Germ cell tumor; Gonadectomy; Gonadectomía; Gonadoblastoma; Intersex; Intersexo; Neoplasia in situ de células germinales; Tumor de células germinales.