Valorisation, Green Extraction Development, and Metabolomic Analysis of Wild Artichoke By-Product Using Pressurised Liquid Extraction UPLC-HRMS and Multivariate Data Analysis

Molecules. 2022 Oct 22;27(21):7157. doi: 10.3390/molecules27217157.

Abstract

Valorisation of food by-products has recently attracted considerable attention due to the opportunities to improve the economic and environmental sustainability of the food production chain. Large quantities of non-edible parts of the artichoke plant (Cynara cardunculus L.) comprising leaves, stems, roots, bracts, and seeds are discarded annually during industrial processing. These by-products contain many phytochemicals such as dietary fibres, phenolic acids, and flavonoids, whereby the most challenging issue concerns about the recovery of high-added value components from these by-products. The aim of this work is to develop a novel valorisation strategy for the sustainable utilisation of artichoke leaves' waste, combining green pressurised-liquid extraction (PLE), spectrophotometric assays and UPLC-HRMS phytochemical characterization, to obtain bioactive-rich extract with high antioxidant capacity. Multivariate analysis of the major selected metabolites was used to compare different solvent extraction used in PLE.

Keywords: antioxidant activities; artichoke leaves by-product; multivariate analysis; phytochemical analysis; pressurised liquid extraction.

MeSH terms

  • Antioxidants / chemistry
  • Cynara scolymus* / chemistry
  • Cynara* / metabolism
  • Data Analysis
  • Multivariate Analysis
  • Phytochemicals / analysis
  • Plant Extracts / chemistry

Substances

  • Antioxidants
  • Phytochemicals
  • Plant Extracts

Grants and funding

This work was partially supported by the Regione Lombardia, Ricerca e Innovazione, within the project Nano CosPha 2020–2021, the Italian Ministry of University and Research (MIUR) through grant “Dipartimenti di Eccellenza: 2017” to University of Milano Bicocca, Department of Biotechnology and Biosciences.