Fibrin-based cardiac patch containing neuregulin-1 for heart repair after myocardial infarction

Tianqi Chang; Chunxia Liu; Hong Yang; Kunyan Lu; Yanchao Han; Yu Zheng; Haoyue Huang; Yong Wu; Yumeng Song; Qian Yu; Zhenya Shen; Tingbo Jiang; Yanxia Zhang

doi:10.1016/j.colsurfb.2022.112936

Fibrin-based cardiac patch containing neuregulin-1 for heart repair after myocardial infarction

Colloids Surf B Biointerfaces. 2022 Dec:220:112936. doi: 10.1016/j.colsurfb.2022.112936. Epub 2022 Oct 14.

Authors

Tianqi Chang¹, Chunxia Liu², Hong Yang², Kunyan Lu³, Yanchao Han², Yu Zheng², Haoyue Huang², Yong Wu², Yumeng Song⁴, Qian Yu⁵, Zhenya Shen⁶, Tingbo Jiang⁷, Yanxia Zhang⁸

Affiliations

¹ Department of Cardiovascular Surgery of the First Affiliated Hospital & Institute for Cardiovascular Science, Suzhou Medical College of Soochow University, Soochow University, Suzhou 215000, PR China; Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou 215006, PR China.
² Department of Cardiovascular Surgery of the First Affiliated Hospital & Institute for Cardiovascular Science, Suzhou Medical College of Soochow University, Soochow University, Suzhou 215000, PR China.
³ State and Local Joint En gineering Laboratory for Novel Functional Polymeric Materials, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, PR China.
⁴ Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou 215006, PR China.
⁵ State and Local Joint En gineering Laboratory for Novel Functional Polymeric Materials, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, PR China; Key Laboratory of Polymeric Materials Design and Synthesis for Biomedical Function, Soochow University, Suzhou 215123, PR China. Electronic address: yuqian@suda.edu.cn.
⁶ Department of Cardiovascular Surgery of the First Affiliated Hospital & Institute for Cardiovascular Science, Suzhou Medical College of Soochow University, Soochow University, Suzhou 215000, PR China. Electronic address: uuzyshen@aliyun.com.
⁷ Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou 215006, PR China. Electronic address: 18906201122@189.cn.
⁸ Department of Cardiovascular Surgery of the First Affiliated Hospital & Institute for Cardiovascular Science, Suzhou Medical College of Soochow University, Soochow University, Suzhou 215000, PR China; Key Laboratory of Polymeric Materials Design and Synthesis for Biomedical Function, Soochow University, Suzhou 215123, PR China. Electronic address: zhangyanxia@suda.edu.cn.

PMID: 36265312
DOI: 10.1016/j.colsurfb.2022.112936

Abstract

Cardiac patch, a scaffold layered on the surface of the heart that can provide mechanical and regeneration support for damaged myocardium, has provided a promising solution to treat severe myocardial infarction (MI). In this work, a fibrin based cardiac patch loaded with neuregulin-1 (NRG-1) is developed to attach locally to the infract area of heart. The composite patch exhibited good biocompatibility and promoted cardiomyocyte proliferation in vitro via NRG-1/ErbB signaling. Moreover, implantation of this patch to the infracted border zone reduced cell apoptosis, promoted angiogenesis and inhibited fibrosis, which reduced infraction size and improved cardiac function consequently. Thus, the combination of natural biomaterial fibrin and bioactive factor NRG-1 might have a promising potential for clinical application of MI treatment.

Keywords: Cardiac patch; Fibrin; Myocardial infarction; Neuregulin-1.

MeSH terms

Fibrin
Heart
Humans
Myocardial Infarction* / drug therapy
Myocardium
Myocytes, Cardiac
Neuregulin-1* / pharmacology
Neuregulin-1* / therapeutic use
Tissue Scaffolds*

Substances

Fibrin
Neuregulin-1