Crosstalk among long non-coding RNA, tumor-associated macrophages and small extracellular vesicles in tumorigenesis and dissemination

Li-Jie Zhang; Feng Chen; Xiao-Ru Liang; Murugavel Ponnusamy; Hao Qin; Zhi-Juan Lin

doi:10.3389/fonc.2022.1008856

Crosstalk among long non-coding RNA, tumor-associated macrophages and small extracellular vesicles in tumorigenesis and dissemination

Front Oncol. 2022 Oct 3:12:1008856. doi: 10.3389/fonc.2022.1008856. eCollection 2022.

Authors

Li-Jie Zhang¹, Feng Chen², Xiao-Ru Liang¹, Murugavel Ponnusamy³, Hao Qin⁴, Zhi-Juan Lin¹

Affiliations

¹ Key Lab for Immunology in Universities of Shandong Province, School of Basic Medical Sciences, Weifang Medical University, Weifang, China.
² Department of General Surgery, Weifang Traditional Chinese Hospital, Weifang, China.
³ Institute for Translational Medicine, Qingdao University, Qingdao, China.
⁴ Department of Public Health, Weifang Medical University, Weifang, China.

Abstract

Long noncoding RNAs (lncRNAs), which lack protein-coding ability, can regulate cancer cell growth, proliferation, invasion, and metastasis. Tumor-associated macrophages (TAMs) are key components of the tumor microenvironment that have a significant impact on cancer progression. Small extracellular vesicles (sEV) are crucial mediators of intercellular communications. Cancer cell and macrophage-derived sEV can carry lncRNAs that influence the onset and progression of cancer. Dysregulation of lncRNAs, TAMs, and sEV is widely observed in tumors which makes them valuable targets for cancer immunotherapy. In this review, we summarize current updates on the interactions among sEV, lncRNAs, and TAMs in tumors and provide new perspectives on cancer diagnosis and treatment.

Keywords: TAMs; lncRNA; sEV; tumor microenvironment; tumorigenesis.

Publication types

Review