Pyrrole-2-carbaldehydes with neuroprotective activities from Moringa oleifera seeds

Yueping Jiang; Rong Liu; Jing Li; Qi Huang; Shao Liu; Jia He

doi:10.1016/j.phytochem.2022.113451

Pyrrole-2-carbaldehydes with neuroprotective activities from Moringa oleifera seeds

Phytochemistry. 2022 Dec:204:113451. doi: 10.1016/j.phytochem.2022.113451. Epub 2022 Oct 17.

Authors

Yueping Jiang¹, Rong Liu¹, Jing Li¹, Qi Huang¹, Shao Liu², Jia He³

Affiliations

¹ Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China; Institute for Rational and Safe Medication Practices, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
² Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China; Institute for Rational and Safe Medication Practices, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China. Electronic address: liushao999@csu.edu.cn.
³ Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China; Institute for Rational and Safe Medication Practices, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China. Electronic address: joeyhe92@126.com.

PMID: 36257341
DOI: 10.1016/j.phytochem.2022.113451

Abstract

Seven undescribed pyrrole-2-carbaldehydes (pyrrolemorines A-G), along with four known analogs, were isolated from the aqueous extract of Moringa oleifera seeds. The structures were elucidated by comprehensive spectroscopic and chemical analyses using HRMS and NMR spectra, acid hydrolysis, and Rh₂(OCOCF₃)₄-induced ECD experiments. Pyrrolemorines A, E, and pyrrolemarumine displayed neuroprotective activities against oxygen-glucose deprivation/reperfusion injury in PC12 cells by regulating NF-κb and Nrf2.

Keywords: Moringa oleifera; Moringaceae; Neuroprotective activities; Pyrrole-2-carbaldehydes; Pyrrolemorines A–G; Seeds; Structure elucidation.