A Post Hoc Analysis of KidneyIntelX and Cardiorenal Outcomes in Diabetic Kidney Disease

Kidney360. 2022 May 18;3(9):1599-1602. doi: 10.34067/KID.0002172022. eCollection 2022 Sep 29.

Abstract

KidneyIntelX, a bioprognostic test for assessing risk of CKD progression, risk stratified individuals for kidney, heart failure, and death outcomes in the Canagliflozin Cardiovascular Assessment Study.Individuals scored as high risk seemed to derive more of benefit from treatment with canagliflozin versus placebo.These findings may serve to increase adoption of underutilized therapies for cardiorenal risk reduction in patients with diabetic kidney disease.

Keywords: chronic renal disease; clinical nephrology; diabetes; diabetes mellitus; diabetic nephropathy.

MeSH terms

  • Canagliflozin / therapeutic use
  • Cardiovascular System*
  • Diabetes Mellitus, Type 2* / complications
  • Diabetic Nephropathies* / drug therapy
  • Humans
  • Sodium-Glucose Transporter 2 Inhibitors* / therapeutic use

Substances

  • Sodium-Glucose Transporter 2 Inhibitors
  • Canagliflozin