Building a kidney tree: Functional collecting duct from human pluripotent stem cells

Zhongwei Li; Nils O Lindström

doi:10.1016/j.devcel.2022.09.009

Building a kidney tree: Functional collecting duct from human pluripotent stem cells

Dev Cell. 2022 Oct 10;57(19):2251-2253. doi: 10.1016/j.devcel.2022.09.009.

Authors

Zhongwei Li¹, Nils O Lindström²

Affiliations

¹ Deptartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; USC/UKRO Kidney Research Center, Division of Nephrology and Hypertension, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. Electronic address: zhongwei.li@med.usc.edu.
² Deptartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. Electronic address: nils.lindstrom@med.usc.edu.

PMID: 36220079
DOI: 10.1016/j.devcel.2022.09.009

Abstract

Human developmental studies and regenerative therapies need in vitro systems that generate cell types recapitulating mature cell physiologies. In a recent issue of Nature Biotechnology, Shi et al. (2022) show how pluripotent stem cells can differentiate into ureteric bud organoids that mature into functional kidney collecting duct cell types.

Publication types

Comment

MeSH terms

Cell Differentiation / physiology
Humans
Kidney* / cytology
Kidney* / metabolism
Organoids
Pluripotent Stem Cells*

Grants and funding

DP2 DK135739/DK/NIDDK NIH HHS/United States