SARS-CoV-2 N protein potentiates host NPM1-snoRNA translation machinery to enhance viral replication

Hui Wang; Danrong Shi; Penglei Jiang; Zebin Yu; Yingli Han; Zhaoru Zhang; Peihui Wang; He Huang; Hangping Yao; Pengxu Qian

doi:10.1038/s41392-022-01210-9

SARS-CoV-2 N protein potentiates host NPM1-snoRNA translation machinery to enhance viral replication

Signal Transduct Target Ther. 2022 Oct 8;7(1):356. doi: 10.1038/s41392-022-01210-9.

Authors

Hui Wang^#^{1

2

3

4}, Danrong Shi^#⁵, Penglei Jiang^{1

2

3

4}, Zebin Yu^{1

2

3

4}, Yingli Han^{1

2

3

4}, Zhaoru Zhang^{1

2

3

4}, Peihui Wang⁶, He Huang^{1

2

3

4}, Hangping Yao⁷, Pengxu Qian^{8

9

10

11}

Affiliations

¹ Center of Stem Cell and Regenerative Medicine, and Bone Marrow Transplantation Center of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
² Liangzhu Laboratory, Zhejiang University Medical Center, 1369 West Wenyi Road, Hangzhou, China.
³ Institute of Hematology, Zhejiang University & Zhejiang Engineering Laboratory for Stem Cell and Immunotherapy, Hangzhou, China.
⁴ School of Medicine, Zhejiang University, Hangzhou, China.
⁵ State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
⁶ Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, Jinan, China.
⁷ State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China. yaohangping@zju.edu.cn.
⁸ Center of Stem Cell and Regenerative Medicine, and Bone Marrow Transplantation Center of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. axu@zju.edu.cn.
⁹ Liangzhu Laboratory, Zhejiang University Medical Center, 1369 West Wenyi Road, Hangzhou, China. axu@zju.edu.cn.
¹⁰ Institute of Hematology, Zhejiang University & Zhejiang Engineering Laboratory for Stem Cell and Immunotherapy, Hangzhou, China. axu@zju.edu.cn.
¹¹ School of Medicine, Zhejiang University, Hangzhou, China. axu@zju.edu.cn.

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

COVID-19* / genetics
Humans
Nuclear Proteins / genetics
RNA, Small Nucleolar
SARS-CoV-2*
Virus Replication / genetics

Substances

Nuclear Proteins
RNA, Small Nucleolar