Keywords: LLU, lower limb ulcer; NA, Necrotic angiodermatitis; RP, Raynaud's phenomenon; Raynaud's phenomenon; SSc, systemic sclerosis; arteriopathy; botulinum toxin (botox); calcinosis; connective tissue disease; lower limb ulcers; lymphangiopathy; macroangiopathy; microangiopathy; naifold videocapillaroscopy; systemic sclerosis; venous insufficiency.