1 AP-HP Sorbonne université, Pitié-Salpêtrière University Hospital, Department of Pharmacology and Clinical Investigation Centre, 47-83 boulevard de l'hôpital, 75013 Paris, France; Inserm, CIC-1901 and UMR-S 1166, Sorbonne University, Faculty of Medicine, 75013 Paris, France. Electronic address: christian.funck-brentano@aphp.fr.