Panning for gold: Purifying mesencephalic dopaminergic progenitors differentiated from human pluripotent stem cells

Qingyuan Tang; Jeffrey S Schweitzer; Bin Song

doi:10.1016/j.stemcr.2022.09.002

Panning for gold: Purifying mesencephalic dopaminergic progenitors differentiated from human pluripotent stem cells

Stem Cell Reports. 2022 Oct 11;17(10):2167-2171. doi: 10.1016/j.stemcr.2022.09.002. Epub 2022 Sep 29.

Authors

Qingyuan Tang¹, Jeffrey S Schweitzer², Bin Song³

Affiliations

¹ Guangdong Provincial Key Laboratory of Brain Function and Disease, Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China; Department of Neurosurgery, Huashan Hospital, Institute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Fudan University, Shanghai 200032, China.
² Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Electronic address: jschweitzer1@mgh.harvard.edu.
³ Department of Neurosurgery, Huashan Hospital, Institute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Fudan University, Shanghai 200032, China. Electronic address: binsong@fudan.edu.cn.

Abstract

In a recently published study, Xu et al. used two surface markers, CLSTN2 and PTPRO, to generate highly purified donor dopaminergic neurons and achieved stable and predictable therapeutic outcomes by transplantation into the brain of PD animal models (Xu et al., 2022).

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MeSH terms

Animals
Cell Differentiation / physiology
Dopamine
Dopaminergic Neurons
Gold*
Humans
Mesencephalon
Pluripotent Stem Cells*

Substances

Gold
Dopamine