Cancer in Inflammatory Bowel Disease

Adam S Faye; Ariela K Holmer; Jordan E Axelrad

doi:10.1016/j.gtc.2022.05.003

Cancer in Inflammatory Bowel Disease

Gastroenterol Clin North Am. 2022 Sep;51(3):649-666. doi: 10.1016/j.gtc.2022.05.003. Epub 2022 Aug 30.

Authors

Adam S Faye¹, Ariela K Holmer¹, Jordan E Axelrad²

Affiliations

¹ Inflammatory Bowel Disease Center at NYU Langone Health, 305 East 33rd Street, Lower Level, New York, NY 10016, USA.
² Inflammatory Bowel Disease Center at NYU Langone Health, 305 East 33rd Street, Lower Level, New York, NY 10016, USA. Electronic address: Jordan.Axelrad@nyulangone.org.

PMID: 36153115
DOI: 10.1016/j.gtc.2022.05.003

Abstract

Inflammatory bowel diseases (IBD), including Crohn disease and ulcerative colitis, are chronic inflammatory conditions of the gastrointestinal tract. Individuals with IBD are at increased risk for several malignancies originating in the intestine, such as colorectal cancer, small bowel adenocarcinoma, intestinal lymphoma, and anal cancer. There are also several extraintestinal malignancies associated with IBD and IBD therapies, including cholangiocarcinoma, skin cancer, hematologic malignancies, genitourinary cancer, cervical cancer, and prostate cancer. The authors summarize the risk of cancer in patients with IBD, diagnosis and management of colorectal neoplasia in IBD, and management of patients with IBD and active or recent cancer.

Keywords: Cancer; Colorectal neoplasia; Crohn disease; Dysplasia; Inflammatory bowel disease; Ulcerative colitis.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Chronic Disease
Colitis, Ulcerative* / diagnosis
Colorectal Neoplasms* / diagnosis
Colorectal Neoplasms* / epidemiology
Colorectal Neoplasms* / etiology
Crohn Disease* / complications
Crohn Disease* / therapy
Humans
Inflammatory Bowel Diseases* / complications
Inflammatory Bowel Diseases* / therapy
Lymphoma* / diagnosis
Lymphoma* / etiology
Lymphoma* / therapy
Male