T cell receptor sequencing reveals reduced clonal breadth of T-cell responses against SARS-CoV-2 after natural infection and vaccination in allogeneic hematopoietic stem cell transplant recipients

A Pradier; A C Mamez; C Stephan; F Giannotti; S Masouridi-Levrat; S Wang; S Morin; D Neofytos; D L Vu; A Melotti; I Arm; C S Eberhardt; J Tamburini; L Kaiser; Y Chalandon; F Simonetta

doi:10.1016/j.annonc.2022.09.153

T cell receptor sequencing reveals reduced clonal breadth of T-cell responses against SARS-CoV-2 after natural infection and vaccination in allogeneic hematopoietic stem cell transplant recipients

Ann Oncol. 2022 Dec;33(12):1333-1335. doi: 10.1016/j.annonc.2022.09.153. Epub 2022 Sep 16.

Authors

A Pradier¹, A C Mamez², C Stephan³, F Giannotti³, S Masouridi-Levrat³, S Wang⁴, S Morin³, D Neofytos⁵, D L Vu⁵, A Melotti⁴, I Arm⁶, C S Eberhardt⁷, J Tamburini⁴, L Kaiser⁸, Y Chalandon¹, F Simonetta⁹

Affiliations

¹ Division of Hematology, Department of Oncology, Geneva University Hospitals, University of Geneva, Geneva; Translational Research Centre in Onco-Haematology, Faculty of Medicine, University of Geneva, Geneva.
² Division of Hematology, Department of Oncology, Geneva University Hospitals, University of Geneva, Geneva. Electronic address: anne-claire.mamez@hcuge.ch.
³ Division of Hematology, Department of Oncology, Geneva University Hospitals, University of Geneva, Geneva.
⁴ Translational Research Centre in Onco-Haematology, Faculty of Medicine, University of Geneva, Geneva.
⁵ Division of Infectious Diseases, Geneva University Hospitals, Geneva.
⁶ Laboratory of Virology, Division of Infectious Diseases and Division of Laboratory Medicine, University Hospitals of Geneva & Faculty of Medicine, University of Geneva, Geneva.
⁷ Center for Vaccinology, University Hospitals of Geneva Division of General Pediatrics, Department of Woman, Child and Adolescent Medicine, Faculty of Medicine, University of Geneva, Geneva.
⁸ Division of Infectious Diseases, Geneva University Hospitals, Geneva; Laboratory of Virology, Division of Infectious Diseases and Division of Laboratory Medicine, University Hospitals of Geneva & Faculty of Medicine, University of Geneva, Geneva; Geneva Centre for Emerging Viral Diseases, Geneva University Hospitals, Geneva, Switzerland.
⁹ Division of Hematology, Department of Oncology, Geneva University Hospitals, University of Geneva, Geneva; Translational Research Centre in Onco-Haematology, Faculty of Medicine, University of Geneva, Geneva. Electronic address: federico.simonetta@unige.ch.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

COVID-19* / prevention & control
Hematopoietic Stem Cell Transplantation* / adverse effects
Humans
Receptors, Antigen, T-Cell
SARS-CoV-2
T-Lymphocytes
Transplant Recipients
Vaccination

Substances

Receptors, Antigen, T-Cell