Autoimmune Diseases Induced or Exacerbated by COVID-19: A Single Center Experience

Yuval Ishay; Ariel Kenig; Limor Rubin; Oded Shamriz; Fadi Kharouf

doi:10.1155/2022/9171284

Autoimmune Diseases Induced or Exacerbated by COVID-19: A Single Center Experience

Autoimmune Dis. 2022 Sep 6:2022:9171284. doi: 10.1155/2022/9171284. eCollection 2022.

Authors

Yuval Ishay¹, Ariel Kenig^{1

2}, Limor Rubin³, Oded Shamriz^{3

4}, Fadi Kharouf⁵

Affiliations

¹ The Institute of Gastroenterology and Liver Diseases, Department of Medicine, Hadassah Medical Organization, The Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
² Department of Medicine, Hadassah Medical Organization, The Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
³ Allergy and Clinical Immunology Unit, Department of Medicine, Hadassah Medical Organization, The Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
⁴ The Lautenberg Center for Immunology and Cancer Research, Institute of Medical Research Israel-Canada, The Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
⁵ The Rheumatology Unit, Hadassah Medical Organization, The Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.

Abstract

The association between infectious diseases and autoimmunity has long been reported. Specifically, during the coronavirus disease 2019 (COVID-19) pandemic, this relation was further emphasized. The interplay between the two disease processes remains interesting, yet incompletely defined. Herein, we report a case series of six patients presenting with autoimmune phenomena first developed or exacerbated following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We describe the disease course and discuss the possible mechanisms underlying the association between autoimmunity and COVID-19.