All That metas─Synthesis of Dispersion Energy Donor-Substituted Benzenes

Org Lett. 2022 Sep 30;24(38):6968-6972. doi: 10.1021/acs.orglett.2c02780. Epub 2022 Sep 15.

Abstract

We report a general and scalable method for the synthesis of all-meta-trisubstituted benzenes from readily available 3,5-disubstituted catechols. Oxidation and [4 + 2] cycloaddition with acetylene dienophiles generate a bicyclo[2.2.2]octane structure that is doubly decarbonylated initiated by blue-light irradiation, leading to a meta,meta-disubstitution pattern on the re-aromatized system. This enables this substitution pattern even with very bulky alkyl groups (deemed excellent dispersion energy donors) to be incorporated into, for example, chiral phosphoric acid catalysts.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylene / chemistry
  • Benzene* / chemistry
  • Catalysis
  • Catechols / chemistry
  • Octanes* / chemistry
  • Phosphoric Acids / chemistry

Substances

  • Catechols
  • Octanes
  • Phosphoric Acids
  • phosphoric acid
  • Benzene
  • Acetylene