Affinity selection mass spectrometry (AS-MS) was recently applied to a new high-throughput binder confirmation (HTBC) platform. The HTBC-AS-MS platform can assess target engagement for hundreds of chemical series per target and is used at GSK to prioritize synthesis decisions for follow-up organic synthesis of DNA-encoded library technology (ELT) hits.
Keywords: Affinity selection; DNA-encoded library (DEL); ELT; Ligand; Mass spectrometry; Proteins; Screening; Small molecules.
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