Nature versus nurture contribution to prostate cancer risk

Stephen J Freedland; Nadine Adriana Friedrich

doi:10.1038/s41585-022-00650-w

Nature versus nurture contribution to prostate cancer risk

Nat Rev Urol. 2022 Nov;19(11):635-636. doi: 10.1038/s41585-022-00650-w.

Authors

Stephen J Freedland^{1

2}, Nadine Adriana Friedrich³

Affiliations

¹ Department of Surgery, Division of Urology and Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA. stephen.freedland@cshs.org.
² Department of Surgery, Section of Urology, Durham VA Medical Center, Durham, NC, USA. stephen.freedland@cshs.org.
³ Department of Surgery, Division of Urology and Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Abstract

Genetics has a role in predisposition towards prostate cancer, and an accurate prediction of prostate cancer risk can be made using polygenic risk scores. New evidence suggests that this risk is modifiable through lifestyle changes, but only in men at a high genetic risk of developing prostate cancer.

Publication types

Comment

MeSH terms

Humans
Male
Prostatic Neoplasms* / epidemiology
Prostatic Neoplasms* / etiology

Grants and funding

T32 CA240172/CA/NCI NIH HHS/United States